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Transcriptome changes of rosacea patients before and after doxycycline by single-cell sequencing

Transcriptome changes of rosacea patients before and after doxycycline by single-cell sequencing

Status
Active, not recruiting
Phases
Phase 4
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2200059531
Enrollment
Unknown
Registered
2022-05-04
Start date
2022-07-01
Completion date
Unknown
Last updated
2024-03-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Rocasea

Interventions

rosacea patients group:Doxycycline
pigmented nevus resection or plastic surgery patients group:None

Sponsors

The Second Affiliated Hospital of Xi'an Jiaotong University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 100 Years

Inclusion criteria

Inclusion criteria: 1. Aged 18-100 years, no gender limit; 2. Patients with papulopustular rosacea confirmed by clinical manifestations; The control group was healthy subjects undergoing plastic surgery; 3. Those who voluntarily participated in the case-control study and signed the informed consent form; 4. Patients with non-scar constitution, that is, those who do not form scars after trauma.

Exclusion criteria

Exclusion criteria: 1. Pregnant and lactating patients or those who have fertility requirements within one year; 2. Patients with depression or other mental illness; 3. Patients with other acne diseases; 4. Coagulation system disorders affecting patients undergoing surgical resection; 5. Patients with liver or kidney insufficiency or other visceral diseases; 6. Patients who have received medical treatment; 7. Patients refused to undergo tissue resection.

Design outcomes

Primary

MeasureTime frame
Immune cells in lesions;Flushing Assessment Tool;Global Flushing Severity Scale;Clinician's erythema assessment;Patient's self-assessment;

Secondary

MeasureTime frame
Quality of life in patients with rosacea;

Countries

China

Contacts

Public ContactLiu Yale

The Second Affiliated Hospital of Xi'an Jiaotong University

liuyale114@163.com+86 29 87679327

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026