postoperative pain
Conditions
Interventions
Group 1 :Sufentanil and esketamine were administered for pain relief
Group 2:Postoperative analgesia was administered with sufentanil
Sponsors
Department of Anesthesiology, Affiliated Hospital of Southwest Medical University
Eligibility
Sex/Gender
Female
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Age: 18-65 years old; 2. ASA score: I-II level; 3. BMI (kg/m2): 18-30; 4. Accept radical cervical cancer surgery under general anesthesia; 5. Have the ability to read and write, and can sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Opioids have been used before surgery; 2. Patients with mental illness; 3. There are any of the following contraindications for the use of esketamine injection: (patients with serious risk of elevated blood pressure or intracranial pressure; patients with intraocular hypertension, glaucoma or penetrating ocular trauma; patients with poorly controlled or untreated hypertension and resting systolic/diastolic blood pressure exceeding 180/110 mmHg; patients with untreated or undertreated hyperthyroidism); 4. Patients allergic to ketamine, propofol, opioids; 5. Patients with unstable ischemic heart disease; 6. Those who are unwilling or unable to use intravenous patient-controlled analgesia (PCIA) pumps; 7. Those who cannot use the pain Numerical Rating Scale (NRS); 8. Plan to enter the ICU after surgery; 9. Participated in clinical trials of other drugs as subjects in the past 3 months.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Visual pain score;Mini-Mental State Examination;Beck depression scale; | — |
Countries
China
Contacts
Public ContactZhan Jian
Affiliated Hospital of Southwest Medical University
Outcome results
None listed