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Predictive Factors and Serum Differential Biomarkers Screening of Persistent Postoperative Pain after Repeated Cecarean Section

Predictive Factors and Differential Polypeptide Screening of Persistent Postoperative Pain in Women Undergoing Repeated Cecarean Section

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2200059487
Enrollment
Unknown
Registered
2022-05-02
Start date
2022-05-18
Completion date
Unknown
Last updated
2026-03-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Pain?Persisitent Postoperative Pain(PPSP)

Interventions

case series:None

Sponsors

Women' Hosipital of Nanjing Medical University (Nanjing Maternity and Child Health Care Hospital)
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
20 Years to 45 Years

Inclusion criteria

Inclusion criteria: 1. Aged 20-45 years; 2. Gestational weeks >= 37 weeks; 3. Single pregnancy scar uterus women; 4. Body mass index <= 35 kg/m2; 5. Accept another elective cesarean section.

Exclusion criteria

Exclusion criteria: 1. Pregnant women with uterine fibroids or ovarian tumors who need intraoperative surgery; 2. Pregnant women with severe preeclampsia; 3. Those who used opioids and other sedative and analgesic drugs within a week; 4. Those with severe heart, lung, liver and kidney dysfunction.

Design outcomes

Primary

MeasureTime frame
Incidence of persistent postsurgery pain (PPSP) occured in 3 months after surgery;—

Secondary

MeasureTime frame
The consumption of opioid drugs;Pain score;Side effects (nausea, vomiting, dizziness, drowsiness, itching, others);Edinburgh postnatal depression scale, EPDS;Postpartum Bonding Questionnaire, PBQ;Generalized Anxiety Disorder, GAD;Fear of pain questionnaire-III, FPQ-III;Basic information of subjects: age, gestational week, height, weight and education level;Information related to the subject's medical history: number of births, time of previous cesarean section, history of pain during pregnancy, scur characteristic and complications during pregnancy;Operation related information: operation duration, bleeding volume, anesthesia method;Maternal and infant outcomes: neonatal Apgar score, neonatal weight, whether the mother and infant are in the same room;Screening of pain markers in maternal peripheral blood: polypeptide screening, proteomics screening and pain index screening;Subacute surgery pain;—

Countries

China

Contacts

Public ContactLi Caijuan

Women' Hosipital of Nanjing Medical University (Nanjing Maternity and Child Health Care Hospital)

lcj_1228@126.com+86 173 7228 3502

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Apr 3, 2026