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Effectiveness and safety of probiotics in relieving constipation: a double-blind, randomized, placebo-controlled study

Effectiveness and safety of probiotics in relieving constipation: a double-blind, randomized, placebo-controlled study

Status
Active, not recruiting
Phases
Phase 1
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2200059480
Enrollment
Unknown
Registered
2022-05-01
Start date
2022-05-15
Completion date
Unknown
Last updated
2024-03-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Constipation

Interventions

Group 1 :Probiotics A
Group 2:Probiotics B

Sponsors

Xinle City Hospital
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: 1. Age 3-70 years old, gender is not limited; 2. Those who meet at least two of the following symptoms: defecation <= 3 times per week, defecation is dry ball feces or hard feces, defecation feels strained, defecation is not complete, and defecation is blocked; 3. No intestinal organic disease; 4. Not taking drugs that can cause constipation within 2 weeks, not using prokinetic drugs, probiotics, and osmotic laxatives; 5. Those who voluntarily sign the informed consent form.

Exclusion criteria

Exclusion criteria: 1. Have used other probiotic drugs for treatment within 3 months before enrollment; 2. Those with gastrointestinal organic diseases; 3. Severe endocrine and metabolic diseases, nervous system diseases; 4. Severe heart, liver, kidney and other organic diseases; 5. Received any type of antibiotic treatment within 6 weeks; 6. Those who have a history of drug or psychotropic substance abuse and cannot quit or have mental disorders; 7. Participated in other clinical trials within three months.

Design outcomes

Primary

MeasureTime frame
symptoms of constipation;

Secondary

MeasureTime frame
intestinal flora;Short-chain fatty acid;blood routine examination;routine urine test;renal function;liver function;

Countries

China

Contacts

Public ContactWei Kang

Hebei Inatural Biotech Co.,Ltd.

weizi_1012@126.con+86 18931197180

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026