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Study of the Effect of Modified- Double Filtration Plasma Pheresis (M-DFPP) on Septic Shock

Study of the Effect of Modified- Double Filtration Plasma Pheresis (M-DFPP) on Septic Shock

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2200059470
Enrollment
Unknown
Registered
2022-04-30
Start date
2022-05-01
Completion date
Unknown
Last updated
2024-03-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Sepsis

Interventions

Group 1 :None
Group 2:Modified double plasmapheresis

Sponsors

Beijing Luhe Hospital, Capital Medical University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: 1. Age > 18 years old; 2. Meet the diagnosis of septic shock (sepsis 3.0) for less than 24 hours; 3. Meet the serious SS standard. Severe SS standard (meeting two or more items): after 1 hour of cluster treatment, it is still: (1) MAP = 2 mmol/L; (3) Central venous oxygen saturation (SCVO 2) = 0.4 ug/kg/min; 4. Obtain written informed consent.

Exclusion criteria

Exclusion criteria: 1. Those who are allergic to citric acid, heparin or protamine; 2. Patients with chronic kidney disease and chronic liver disease in the past; 3. Patients with severe craniocerebral injury and cerebral hemorrhage; 4. Expected survival time < 48 h; 5. Pregnancy; 6. Those who are allergic to blood transfusion products; 7. Those who give up treatment during the study period.

Design outcomes

Primary

MeasureTime frame
Day 28 all-cause mortality;—

Countries

China

Contacts

Public ContactYibing Weng

Beijing Luhe Hospital, Capital Medical University

yibingweng@ccmu.edu.cn+86 13911904415

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026