Parkinson's disease
Conditions
Interventions
Group 1:Stimulate the cortical site with the strongest functional connection of STN and GPi on the affected side
Group 2:Stimulate the hand Hotspot (M1) at the traditionally positioned stimulation target
Sponsors
Hangzhou Normal University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Meet the diagnostic criteria for Parkinson's disease; 2. H-Y classification = 1; 4. The age of onset is over 40 years old, the symptoms have lasted for more than 1 year, and the drug regimen has not been adjusted within one month; 5. Able to accept TMS therapy, I and my guardian agree to treat and observe according to this study; 6. The fMRI scan can be successfully completed, and the head movement does not exceed 5 mm and 5 degrees during data analysis (two-person analysis, cross-validation).
Exclusion criteria
Exclusion criteria: 1. Severe organic brain diseases, such as epilepsy, stroke, encephalitis, traumatic brain injury, etc., or serious physical diseases such as malignant tumors, acute heart failure, multiple organ failure, etc.; 2. History of mental illness, alcohol and drug dependence; 3. Metal implants placed above the chest, especially in the brain or heart; 4. Pregnant or lactating women.
Countries
China
Contacts
Public ContactYufeng Zang
Hangzhou Normal University
Outcome results
None listed