Espiratory depression caused by sufentanil
Conditions
Interventions
SD:sufentanil combination with dezocine
CG:Sufentanil alone
Sponsors
The First Affiliated Hospital of Anhui Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1. Elective general anesthesia surgery; 2. ASA I-II; 3. Aged 18-60 years; 4. BMI 18-24 kg/m2; 5. No history of mental illness or long-term use of psychiatric drugs (dementia, schizophrenia), history of chronic analgesic use, history of alcoholism; 6. No asthma, chronic bronchitis and other respiratory diseases; 7. No obvious abnormality was found in respiratory and circulatory and liver and kidney functions; 8. No obvious endocrine and metabolic diseases; 9. Preoperative arterial blood gas analysis was normal.
Exclusion criteria
Exclusion criteria: 1. With a history of chronic cough; 2. Any sign of upper respiratory infection; 3. A history of chronic pain; 4. Asthma; 5. Smoking; 6. Prior treatment with angiotensin-converting enzyme inhibitors, with a history of bronchodilator or steroid therapy; 7. Allergic to narcotic drugs.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Median effective dose;Respiratory rate;Apnea time; | — |
Secondary
| Measure | Time frame |
|---|---|
| Observer’s assessment of alertness/sedation;Blood pressure;Heart rate;Pulse Oxygen Saturation;PETCO2; | — |
Countries
China
Contacts
Public ContactXu Guanghong
The First Affiliated Hospital of Anhui Medical University
Outcome results
None listed