Bladder Cancer
Conditions
Interventions
POPRC group:Pelvic organ-preserving radical cystectomy and orthotopic neobladder
SRC group:Standard radical cystectomy and orthotopic neobladder
Sponsors
Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University
Eligibility
Sex/Gender
Female
Age
55 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Female patients aged between 55-75. 2. Patients who are diagnosed with organ-confined urothelial carcinoma(<pT3) 3. Patients who are capable of radical cystectomy with orthotopic ileal neobladder. 4. ECOG score between 0-2; 5. Normal renal function; 6. Patients who volunteer to participate in this study sign the informed consent. 7. Patients who are able to cooperate.
Exclusion criteria
Exclusion criteria: 1. Absence of tumour in bladder neck or urethra; 2. Patients who are diagnosed distant metastasis before surgery; 3. Previous history of malignancy of reproductive organs or surgical resection of reproductive organs; 4. Patients who are diagnosed with other malignancies; 5. Patients who had received pelvic radiotherapy or major pelvic operation; 6. Pregnancy status; 7. Any other conditions that the researcher considers to be excluded from this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Daytime and night-time continence rate [ Time Frame: 6 months ]; | — |
Secondary
| Measure | Time frame |
|---|---|
| Postoperative sexual function [ Time Frame: 6 months ];Perioperative complication rate;5-year overall survival rate;5-year recurrence-free survival rate;Operative time;Estimated blood loss; | — |
Countries
China
Contacts
Public ContactZhong Wenlong
Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University
Outcome results
None listed