Short-term and long-term effects of dexmedetomidine combined with etomidate on postoperative cognitive dysfunction in elderly patients

Short-term and long-term effects of dexmedetomidine combined with etomidate on postoperative cognitive dysfunction in elderly patients: A randomized controlled trial

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2200059363

Enrollment

Unknown

Registered

2022-04-28

Start date

2022-05-01

Completion date

Unknown

Last updated

2024-03-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Postoperative cognitive dysfunction

Interventions

Control group:Sedative propofol

Etomidate group:Sedative Etomidate

Combined drugs group:Sedative etomidate and dexmedetomidine

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Consent to participate in this trial; 2. 60 years <= age <= 90 years; 3. ASA classification II-III; 4. Operation time <= 3 hours.

Exclusion criteria

Exclusion criteria: 1. Severe cardiac, pulmonary, hepatic or renal abnormalities, severe visual and hearing impairment, Parkinson's, Alzheimer's or other central nervous system diseases; 2. Body mass index (BMI) >=30 or <=18.5; 3. Current or prolonged preoperative sedative or antidepressant use; 4. History of cardiac or neurosurgical surgery; 5. Alcohol, drug dependence, or drug abuse; 6. Pulmonary infection or surgical infection; 7. Intraoperative use of atropine anticholinergics; 8. no education (less than primary school education) or a score of <=23 on the Simple Measures Method (MMSE) or previous relevant neuropsychological testing.

Design outcomes

Primary

Measure	Time frame
Incidence of postoperative cognitive dysfunction;	—

Countries

China

Contacts

Public ContactJun Ji

Air Force Medical Center, PLA

joseph79228@sina.com+86 15611934535

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026