Hypotension
Conditions
Interventions
Experimental group:Esketamine intravenously
Control group:Propofol intravenously
Sponsors
Affiliated Cancer Hospital of Guizhou Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1. Age: 18-60 years old, no gender limitation; 2. Patients undergoing elective surgery under general anesthesia and single endotracheal intubation; 3. ASA I or II; 4. 18 kg/m2 < BMI < 28kg/m2; 5. They clearly understood and voluntarily participated in the study and signed informed consent.
Exclusion criteria
Exclusion criteria: 1. Patients who have not received regular antihypertensive therapy or have poor blood pressure control (systolic blood pressure >=160 mmHg or =100 mmHg); 2. Sinus bradycardia, pathological sinus syndrome, and other arrhythmias. 3. Uncontrolled diabetes, coronary heart disease; 4. With central nervous system diseases; 5. Difficult airway; 6. Allergy to research drugs; 7. Discontinuous or long-term use of benzodiazepines or opioids within 2 months before admission; 8. Untreated or uncontrolled hyperthyroidism; 9. Participated in clinical trials of other drugs as a subject within the last 3 months.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Blood pressure; | — |
Secondary
| Measure | Time frame |
|---|---|
| Heart rate;The injection pain;Endotracheal intubation response; | — |
Countries
China
Contacts
Public ContactRui Li
Affiliated Cancer Hospital of Guizhou Medical University
Outcome results
None listed