aortic dissection
Conditions
Interventions
Steriods group:During the induction of anesthesia, 10ml of sterilized water for injection dissolved with 500mg methylprednisone (Pfizer manufacturing Belgium NY) is injected intravenously
placebo group:During the induction of anesthesia, 10ml of sterilized water for injection is injected intravenously
Sponsors
Chinses Academy of Medical Sciences, Fuwai Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Age = 18 years old; 2. Patients with acute type A aortic dissection; 3. Emergency total aortic arch replacement: 4. During the operation, hypothermic circulatory arrest combined with selective cerebral perfusion was used; 5. Get the informed consent of the subject or his guardian.
Exclusion criteria
Exclusion criteria: 1. There were neurological deficits before operation; 2. Preoperative arterial blood gas PaO2/FiO2 = 200mmHg; 3. Patients with a history of bacterial or fungal infection 30 days before inclusion in the study; 4. Patients who are allergic or intolerant to glucocorticoids; 5. Patients who must use glucocorticoids due to their illness; 6. Other conditions judged by the researcher as unsuitable for enrollment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of vital organ injury within 30 days after operation (or before discharge); | — |
Secondary
| Measure | Time frame |
|---|---|
| Postoperative neulogic defict;Postoperative acute kidney injury(KDIGO II -III);Postoperaitve respiratory syndrome;Postoperative acutekidney injury;postoperative renal replacement therapy;Postoperative use of IABP/ECMO;chest drainage in 24hours postoperatively;re-thoratomy;allogenetic transfusion;Mechanical ventilation time;ICU duration;Hospital stay;Infection;wound unhealed;gastrointestinal bleeding/perforation;Intraoperative/postoperative insulin use; | — |
Countries
China
Contacts
Public ContactJi Bingyang
Chinses Academy of Medical Sciences, Fuwai Hospital
Outcome results
None listed