Traumatic brain injury
Conditions
Interventions
Transcranial magnetic stimulation combined with donepezil group:Transcranial magnetic stimulation combined with donepezil
Transcranial direct current stimulation combined with donepezil group:Transcranial direct current stimulation combined with donepezil
Sponsors
Lanzhou University Second Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Patients aged 18-60 years; 2. Meet the diagnostic criteria of brain injury in Modern Neurosurgery (Second Edition) in 2015, that is, have a clear history of brain injury; 3. Those with intracranial hemorrhage or brain contusion confirmed by CT or MRI, and the clinical diagnosis result is severe brain injury; 4. The patient with closed craniocerebral injury whose course of disease is less than 3 months is stable; 5. Patients with clear mind and no aphasia who can cooperate independently to complete treatment and evaluation; 6. There is clear cognitive impairment after brain injury, and there is no cognitive impairment before injury; 7. The family members or patients agreed and signed the informed consent after being informed of the condition in detail.
Exclusion criteria
Exclusion criteria: 1. Patients with worsening condition and new cerebral infarction and cerebral hemorrhage; 2. People with epilepsy, serious heart and lung disease, malignant tumor and psychiatric history; 3. Patients with aphasia and comprehension disorders at the same time; 4. There are metal implants in the body, such as cardiac pacemaker or cochlear implant, or there are implanted materials in the brain (such as deep brain electrode, ventriculo-peritoneal shunt, aneurysm clip); 5. Patients with contraindication of hyperbaric oxygen, patients with drug allergy to olactam and donepezil; 6. Patients who are unwilling or unable to complete the Montreal cognitive assessment (MOCA).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Montreal Cognitive Assessment (MoCA);Minimum Mental State Examination(MMSE); | — |
Secondary
| Measure | Time frame |
|---|---|
| Modified Barthel index rating scale(MBI); | — |
Countries
China
Contacts
Public ContactYumei Ma
Lanzhou University Second Hospital
Outcome results
None listed