Effects of lidocaine and dexmedetomidine on the dosage of sufentanil in thoracic surgery under the guidance of surgical plethysmography index (SPI)

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2200059253

Enrollment

Unknown

Registered

2022-04-27

Start date

2022-06-01

Completion date

Unknown

Last updated

2024-02-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Frugal opioids

Interventions

Dexmedetomidine group:Ten minutes before anesthesia induction, dexmedetomidine 0.5 UG / kg was injected intravenously, then 20 ml syringe was put into the amount of 0.2 UG / kg / h, normal saline was

lidocaine group:Ten minutes before anesthesia induction, lidocaine 1mg / kg was injected intravenously, then 20ml syringe was put into the amount of 1mg / kg / h, normal saline was diluted to 20ml, an

Normal saline group:Ten minutes before anesthesia induction, normal saline of the same volume was injected intravenously, and then pumped continuously at the speed of 20ml / h until the end of the ope

Eligibility

Sex/Gender

All

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: 1. Those who have obtained informed consent; 2. ASA grade I~II; 3. Age 18-65; 4. BMI18-25 kg/m2; 5. It is planned to perform lung wedge resection and segmental or lobectomy under single-hole thoracoscope.

Exclusion criteria

Exclusion criteria: 1. Including difficulty in inserting double-lumen bronchial catheter; Hypertension patients; 2. History of drug use that may affect autonomic nervous regulation, such as ß- Receptor blocker or clonidine; 3. Serious cardiopulmonary disease (pacemaker implantation, atrial fibrillation); 4. Bradycardia (heart rate<60 beats/min); 5. Endocrine diseases (diabetes, thyroid dysfunction); 6. Peripheral neuropathy or terminal cold; Abnormal liver and kidney function; 7. Have a history of abuse of opiates or other analgesics; 8. Contraindications of lidocaine and flurbiprofen ester; 9. Changes in surgical procedures; Atropine or other cardiovascular drugs are required during surgery.

Design outcomes

Primary

Measure	Time frame
Dosage of sufentanil during and after operation;	—

Secondary

Measure	Time frame
Hemodynamic changes;Time of extubation in recovery room after operation;NRS pain score after conscious extubation and pain score at 4, 8, 12 and 24 hours after operation;	—

Countries

China

Contacts

Public ContactJi Fuhai

Changshu Second People's Hospital

Jifuhai@hotmail.com+86 13656207331

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026