Gut microbiota
Conditions
Interventions
Intervention group:atorvastatin calcium tablets, 20mg qd po, for 5 days
Sponsors
Renji Hospital, Shanghai Jiao Tong University School of Medicine
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. 23-33 years old healthy male or female; 2. Normal blood lipids and normal liver function; 3. The subjects participated voluntarily and signed the informed consent.
Exclusion criteria
Exclusion criteria: 1. Pregnancy or breastfeeding; 2. History of colorectal disease or familial history of colorectal-related disease; 3. History of liver disease; 4. Use of antibiotics or probiotics 4 weeks before starting the study; 5. Regular use of aspirin, non-aspirin non-steroidal anti-inflammatory drugs, metformin, or statins; 6. Adverse reactions to statins in the past; 7. History of rhabdomyolysis; 8. Serious diseases, such as cancer and coronary heart disease; 9. History of gastrointestinal and other general anesthesia operations; 10. Infectious diseases such as hepatitis B and tuberculosis; 11. Abuse of alcohol or drugs; 12. Subjects that the researcher believes are not suitable for inclusion.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Gut microbiota (Lactobacillus genus); | — |
Secondary
| Measure | Time frame |
|---|---|
| Fecal metabolites; | — |
Countries
China
Contacts
Public ContactJing-Yuan Fang
Renji Hospital, Shanghai Jiao Tong University School of Medicine
Outcome results
None listed