Moyamoya Disease
Conditions
Interventions
side to side anastomosis group:side to side anastomosis "flow self-regulated bypass surgery"
end to side anastomosis group:Conventional end to side anastomosis "flow control bypass surgery"
Sponsors
Zhongnan hospital of Wuhan university
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: A. patient aged between 6 to 75; B. Diagnostic criteria of moyamoya disease. Diagnosis by digital subtraction angiography (DSA) is based on the following criteria: (1) arterial stenosis or occlusion at the end of the ICA and/or the initial segment of the MCA and/or ACA; (2)Moyamoya-like vascular network is present; (3) Other diseases associated with moyamoya syndrome (MMS) are excluded, such as intracranial atherosclerosis, systemic vasculitis, Down syndrome, acute stroke, hyperthyroidism, meningitis , neurofibromatosis, previous skull base radiation therapy, leptospirosis infection, or autoimmune disease; C. Meet the surgical indications of moyamoya disease. The surgical indications should comply with the 2012 Japanese guidelines for the diagnosis and treatment of moyamoya disease: (1) there have been disease-related symptoms of cerebral ischemia, including TIA, reversible ischemic neurological deficit, cerebral infarction, cognitive decline, limb involuntary movement, headache and seizures; (2) Evidence suggests that there is a decline in cerebral blood flow reserve, including local cerebral blood flow and cerebral blood flow reserve; (3) Presence of disease-related intracerebral hemorrhage and exclusion of other causes; (4) Other surgical contraindications were excluded;
Exclusion criteria
Exclusion criteria: Patients who were unable to follow up or refused to follow up due to other diseases or accidental deaths after surgery
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Bypass success rate;Changes of cerebral blood flow during and after operation;Perioperative complications: hyperperfusion and blood flow hedging;Revascularization effect after operation;Influence on cognitive function of patients;Improvement of the patient's clinical symptoms; | — |
Secondary
| Measure | Time frame |
|---|---|
| Incidence of major clinical events 1 year after primary surgery;The bypass success rate of 1 year after the first operation; | — |
Countries
China
Contacts
Public ContactZhang Jianjian
Zhongnan hospital of Wuhan university
Outcome results
None listed