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Half-normal vs. normal saline for catheter irrigation during ablation of outflow tract ventricular arrhythmias: a multi-center, parallel, open label, randomized study

Half-normal vs. normal saline for catheter irrigation during ablation of outflow tract ventricular arrhythmias: a multi-center, parallel, open label, randomized study

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2200059205
Enrollment
Unknown
Registered
2022-04-26
Start date
2022-05-01
Completion date
Unknown
Last updated
2024-02-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Outflow tract ventricular arrhythmias

Interventions

test group: half-normal saline irrigated RFA
Control group :normal saline irrigated RFA

Sponsors

The First Affiliated Hospital with Nanjing Medical University (Jiangsu Province Hospital)
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 75 Years

Inclusion criteria

Inclusion criteria: 1.Left or right outflow tract premature ventricular contraction or ventricular tachycardia; 2.Patients with symptomatic outflow tract ventricular arrhythmia who do not respond to treatment with at least one antiarrhythmic drug; 3.18-75 years old,regardless of gender; 4.Signed informed consent.

Exclusion criteria

Exclusion criteria: 1. Patients with correctable PVC/VT; 2. Patients with NYHA class III/IV; 3. Patients with serious lung disease; 4. Patients with a history of myocardial infarction and coronary stent implantation in the last 6 months; 5. Patients expected to transplant heart within 12 months; 6. Patients with severe acute cerebral infarction; 7. Patients with hematopoietic diseases; 8. Patients with abnormal liver and kidney function; 9. Pregnancy and Nursing mothers; 10. Patients with psychosis; 11. Life expectancy less than two years.

Design outcomes

Primary

MeasureTime frame
success rate of PVC/VT ablation;

Secondary

MeasureTime frame
ablation time required for PVC disappearance;Perioperative serious complications (cardiac tamponade requiring surgical intervention, arteriovenous fistula or aneurysm,Atrioventricular block requiring pacing therapy);Perioperative non-serious complications (complications other than serious complications);

Countries

China

Contacts

Public ContactZhang Fengxiang

The First Affiliated Hospital of Nanjing Medical University

njzfx6@163.com+86 13952037301

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 11, 2026