Renal cancer
Conditions
Interventions
Radiation therapy group:Radiation therapy
Sponsors
Peking University First Hospital
Eligibility
Sex/Gender
All
Age
12 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Renal cell carcinoma (RCC) with the following characteristics 1) Limited period RCC that cannot be operated due to the following reasons:; Localized RCC confirmed by histology is not expected to be removed after comprehensive evaluation by urologists Or after evaluation by urology department and physician, it is considered that the operation cannot be tolerated due to poor general conditions (those who are not suitable for open surgery, those who need to keep nephron as much as possible, those who have contraindications to general anesthesia, those who have serious complications, severe renal insufficiency, and simultaneous renal cell carcinoma) Or refuse to perform surgery; 2) Transferable RCC; Metastatic RCC confirmed by histology or PET/CT, or more definite metastasis considered by imaging doctors, radiotherapy departments and urologists through comprehensive evaluation of medical history, physical examination and imaging examination. 2. The expected survival period is more than 6 months; 3. Age>12 years old; 4. ECOG 0-1 points; 5. Leukocyte = 3.5 × 10 * 9/l, neutrophil = 1.5 × 10 * 9/l, platelet = 100.0 × 10 * 9/l, hemoglobin = 90g/l; 6. Informed consent of patients.
Exclusion criteria
Exclusion criteria: 1. Have a history of malignant tumor (except for skin cancer without malignant melanoma, cervical cancer in situ, and tumors that have been cured for more than 5 years); 2. Have received radiotherapy for this part; 3. Weight loss>10% within 6 months; 4. Those who have or are combined with hemorrhagic diseases; 5. Active infection; 6. Clinically obvious cardiac diseases (such as drug-controlled hypertension, unstable angina pectoris, congestive heart failure (NYHA) = Grade II, unstable symptomatic arrhythmia or = Grade II peripheral vascular disease); 7. Patients with coronary heart disease who have been receiving interventional therapy or stopped anticoagulant drugs such as aspirin for less than 6 months; 8. Those who are unable to give informed consent due to psychological, family, social and other factors.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| side effects;progression-free survival,PFS; | — |
Secondary
| Measure | Time frame |
|---|---|
| objective response rate, ORR;overall survival, OS; | — |
Contacts
Public ContactXianshu Gao
Peking University First Hospital
Outcome results
None listed