Type 2 diabetes mellitus
Conditions
Interventions
control group:Pioglitazone metformin + orlistat a placebo
experimental group:Pioglitazone and metformin tablets + orlistat capsules
Sponsors
Shanghai Tenth People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Diagnostic criteria for diabetes in patients with type 2 diabetes; 2. Fasting blood glucose =28.0 kg/m^2; 5. Female patients did not plan to have children during the study and took corresponding contraceptive measures (excluding contraceptive pills); 6. C peptide index > 0.3ng/ml.
Exclusion criteria
Exclusion criteria: 1. Abnormal liver function, ALT, AST is more than 2.5 times the upper limit of normal; 2. Renal function impairment, serum creatinine: female >=133µmol/L, male >=135µmol/L; eGFR grading >=60ml/min/1.73m^2; 3. Patients with severe chronic gastrointestinal diseases: chronic malabsorption syndrome or cholestasis; Having undergone enterectomy or other abdominal surgery; Active stage of digestive tract ulcer; 4. Patients with severe heart, lung, liver and kidney diseases and tumor history; 5. Patients with mental disorders, drug or other substance abuse; 6. Allergic to orlistat, metformin, pioglitazone or any of the ingredients or frequent hypoglycemia; 7. History of brittle fractures caused by osteoporosis and non-violent fractures within the past 6 months; 8. Pregnant or lactating patients; 9. Patients considered unsuitable for this study by the investigators.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| HbA1C;height;weight;waist;hip circumference;oral glucose tolerance test;fasting blood-glucose;insulin;blood fat; | — |
Countries
China
Contacts
Public ContactQu Shen
Outcome results
None listed