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Observation of brain function reorganization in patients with spinal cord disease based on fNIRS and the improvement mechanism of rTMS on motor function of patients

Observation of brain function reorganization in patients with spinal cord injury and spinal cord demyelinating disease based on functional near-infrared spectroscopy and the improvement mechanism of repetitive transcranial magnetic stimulation on motor function of patients

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2200059189
Enrollment
Unknown
Registered
2022-04-26
Start date
2022-05-01
Completion date
Unknown
Last updated
2024-02-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

spinal cord disease

Interventions

Case group:Repeat transcranial magnetic stimulation
Control group:Repeat transcranial magnetic stimulation

Sponsors

Tianjin Medical University General Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 55 Years

Inclusion criteria

Inclusion criteria: 1. Patients meeting the above international criteria for neurological classification of spinal cord injury (ASIA criteria) at grade B, C, and D; 2. Aged range from 18 to 55 years; 3. Edinburgh handedness examination determined that the patient was right-handedness; 4. Clear consciousness, no dementia, aphasia, able to follow instructions; 5. There was no history of mental illness or epilepsy, and no obvious abnormality was found in conventional MRI scan; 6. Inpatients without serious heart, liver or kidney diseases who can cooperate with the study; 7. Sign the informed consent form.

Exclusion criteria

Exclusion criteria: 1. SCI patients with craniocerebral injury and lower limb peripheral nerve injury; 2. Contraindications of fNIRS or rTMS exist.

Design outcomes

Primary

MeasureTime frame
ASIA Motor Function Score;ASIA Sensory Score;

Secondary

MeasureTime frame
Fugl-Meyer Scale Score;Modified Ashworth Assessment of Spasticity;Muscle strength assessment;Modified Barthel Index (MBI) ;Holden Functional Classification of Walking;Berg Balance Scale;Central motor conduction time;Motor evoked potential cortical latency;

Countries

China

Contacts

Public ContactWan Chunxiao
wcx2226@163.com+86 22 7306114

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026