Skip to content

Mechanism of intestinal flora affecting antidepressant efficacy of serotonin reuptake inhibitor through metabolic pathway

Mechanism of intestinal flora affecting antidepressant efficacy of serotonin reuptake inhibitor through metabolic pathway

Status
Active, not recruiting
Phases
Early Phase 1
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2200059184
Enrollment
Unknown
Registered
2022-04-26
Start date
2022-04-30
Completion date
Unknown
Last updated
2024-02-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Major depression disorder

Interventions

case series:None

Sponsors

Wuxi Mental Health Center
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 80 Years

Inclusion criteria

Inclusion criteria: 1. Meet the DSM-V clinical diagnostic criteria for depression; 2. Hamilton depression score should be greater than or equal to 18 points; 3. Aged >=18 years; 4. Patients with first-time depression who have not taken any other antidepressants; 5. Able to understand and cooperate with the completion of scale assessment.

Exclusion criteria

Exclusion criteria: 1. Patients with other mental diseases or previous mental diseases; 2. Previous organic brain lesions or severe external injuries to the brain; 3. Patients with severe heart, liver and kidney insufficiency, metabolic diseases and other serious physical diseases; 4. Pregnant or lactating patients; 5. Have taken or used antibiotics (or) microecological regulators continuously within the past month; 6. Abnormal laboratory routine examination (such as liver function, blood routine and urine routine); 7. Participated in another clinical study within 3 months; 8. Patients with serious suicidal tendencies.

Design outcomes

Primary

MeasureTime frame
Intestinal flora;Inflammatory factor;

Countries

China

Contacts

Public ContactJiang Ying

Wuxi Mental Health Center

jiangying911010@163.com+86 13806165971

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026