gout
Conditions
Interventions
Intervention group:Low purine balanced diet
Sponsors
Affiliated Hospital of Qingdao University
Eligibility
Sex/Gender
Male
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18-75 years, male, in line with the 2015ACR/ELUAR clinical diagnostic criteria for gout; 2. Have not taken any urate-lowering medication other than buxostat in the last 1 month; 3. Obtain consent from subject, or family member, or guardian, or legal representative and sign informed consent.
Exclusion criteria
Exclusion criteria: 1. Severe malnutrition; 2. Use of corticosteroids, antituberculosis drugs (e.g., ethambutol, pyrazinamide), anticoagulants (e.g., warfarin or other coumarin-based anticoagulants, bivaluludine), immunosuppressants (e.g., cyclosporine, tacrolimus), azathioprine, 6-mercaptopurine, cyclophosphamide, sulfamethoxazole, trimethoprim, theophylline, niacin, diuretic, estrogen and other drugs that affect uric acid metabolism within 2 weeks prior to randomization, or plan to use them after randomization; 3. Patients with active liver disease or abnormal liver function (ALT and AST are 3 times or more than the upper limit of normal value), patients with impaired kidney function (Cr value exceeds the upper limit of normal value); 4. Patients with severe hypertension (160mmHg/100mmHg) and uncontrolled diabetes after intervention; 5. Secondary hyperuricemia and gout, such as hyperuricemia caused by congenital metabolic diseases, myeloproliferative diseases, diabetic ketoacidosis, renal failure, tumor chemotherapy and/or radiotherapy, etc.; 6. Patients with serious diseases of the heart, lung, central nervous system or malignant tumors, complicated with hematopoietic system and other serious complications; 7. Severe deformities of late gout arthritis; 8. History of alcohol, drug or substance abuse within the last 1 year; 9. Brain disease, abnormal judgment ability, mental illness can not cooperate; 10. Participated in other clinical trials within three months before the screening of this trial; 11. Other researchers did not consider it appropriate to participate in the trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| uric acid; | — |
Secondary
| Measure | Time frame |
|---|---|
| glucose;triglyceride;cholesterol;creatinine;urea nitrogen;uric acid excretion rate;transaminase;blood pressure;body composition; | — |
Countries
China
Contacts
Public ContactZhao Ting
Affiliated Hospital of Qingdao University
Outcome results
None listed