colorectal cancer liver metastasis
Conditions
Interventions
Experimental group:Resection combined with ablation and stereotactic radiotherapy
Sponsors
Beijing Cancer Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Histologically confirmed liver metastases of colorectal cancer were evaluated as technically unresectable after systemic intravenous chemotherapy or hepatic arterial infusion chemotherapy. 2. According to RECIST V1.1, there was at least one measurable lesion in the liver. 3. The number of liver metastases should be at least 3; No unresectable extrahepatic metastases (except lung metastases). 4. Focal diameter =40% of total liver volume, and there is open flow out of liver and into liver. 5. Primary colorectal cancer is evaluated and radical resection is expected. 6. Aged 18-80 years. 7. ECOG physical state score 0 or 1. 8. With full organ and bone marrow function. 9. Expected survival >=12 weeks. 10. Sign a written informed consent and be able to comply with the visit and related procedures stipulated in the program.
Exclusion criteria
Exclusion criteria: 1. Previous history of hepatectomy or ablation (except preoperative radiofrequency ablation performed as planned). 2. Patients with arteriovenous thromboembolism events within the past 6 months who were assessed as unsuitable for surgery. 3. Diagnosis of other malignancies within 5 years prior to treatment. 4. Those who are unwilling or unable to use acceptable methods of contraception throughout the treatment period. 5. Other factors led the researchers to consider it inappropriate to participate in this experiment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Recurrence free survival; | — |
Secondary
| Measure | Time frame |
|---|---|
| Overall survival; | — |
Countries
China
Contacts
Public ContactXing Baocai
Beijing Cancer Hospital
Outcome results
None listed