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A multicenter observational study to evaluate the efficacy and safety of amoxicillin combined with vonoprazan in the eradication of Helicobacter pylori

A multicenter observational study to evaluate the efficacy and safety of amoxicillin combined with vonoprazan in the eradication of Helicobacter pylori - A study to evaluate the efficacy and safety of amoxicillin combined with vonoprazan in the eradication of Helicobacter pylori

Status
Active, not recruiting
Phases
Phase 4
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2200059120
Enrollment
Unknown
Registered
2022-04-25
Start date
2022-05-10
Completion date
Unknown
Last updated
2024-02-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Helicobacter pylori infecion

Interventions

Group A:Amoxicillin + clarithromycin + bismuth + eprazole
Group B:Amoxicillin+vonolsen 10 days
Group C:Amoxicillin+vonolsen 14 days

Sponsors

Fujian Provincial Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 70 Years

Inclusion criteria

Inclusion criteria: 1. Adult patients, aged 18-70 years; 2. No antibiotics, bismuth and Chinese medicine were taken 4 weeks before treatment, and no PPI, H2 receptor antagonist and other drugs were taken 2 weeks before treatment; 3. Positive HP was diagnosed by C13 or C14-urea breath test and rapid urease test; 4. Patients were informed and consented to participate in this study, and their medical records and follow-up records were complete.

Exclusion criteria

Exclusion criteria: 1. Patients with severe heart, lung and renal insufficiency and low immunity; 2. Patients with drug allergy contraindications; 3. Patients with mental illness or communication disorder; 4. Pregnancy and lactation; 5. Gastrointestinal tumors, gastrointestinal bleeding and other organic lesions.

Design outcomes

Primary

MeasureTime frame
eradication rate;

Secondary

MeasureTime frame
degree of clinical symptom remission;adverse reaction;

Countries

China

Contacts

Public ContactLin Zhihui

Fujian Provincial Hospital

13799371368@qq.com+86 13799371368

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026