Observation of olanzapine on prevention of nausea and vomiting after general anesthesia in gynecological laparoscopic surgery

To evaluate the efficacy of single dose oral olanzapine in the prevention of postoperative nausea and vomiting in patients undergoing laparoscopic gynecological surgery under general anesthesia

Status

Active, not recruiting

Phases

Phase 4

Study type

Observational

Source

ChiCTR

Registry ID

ChiCTR2200059115

Enrollment

Unknown

Registered

2022-04-25

Start date

2022-06-01

Completion date

Unknown

Last updated

2024-02-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

The experimental group:Oral olanzapine

The control group:Placebo

Eligibility

Sex/Gender

Female

Age

18 Years to 75 Years

Inclusion criteria

Inclusion criteria: Patients undergoing gynecological laparoscopic surgery under general anesthesia in our hospital, ASA grade I-II, aged 18-75 years, had at least two risk factors for postoperative nausea and vomiting (PONV).

Exclusion criteria

Exclusion criteria: 1. Patients with mental illness or history of mental illness; 2. History of chemotherapy; 3. Have a history of vestibular disturbance or dizziness or nausea or vomiting within 24 hours before surgery, or are receiving routine antiemetic treatment, including systemic corticosteroids; 4. Pregnant or nursing patients; 5. Patients allergic to olanzapine; 6. Myocardial infarction or unstable angina 6 months before the planned operation; 7. History of severe arrhythmias (e.g., VT or VF); 8. Heart failure grade II or higher (NYHA); 9. Postural hypotension or vasovagal syncope 6 months before planned surgery; 10. Inability to swallow medication.

Design outcomes

Primary

Measure	Time frame
The number and extent of nausea and vomiting;	—

Secondary

Measure	Time frame
Use of analgesics and antiemetics;	—

Countries

China

Contacts

Public ContactChen Nanjin

Department of Anesthesiology, Taizhou Hospital, Zhejiang Province

chennj@enzemed.com+86 13750668783

Outcome results