cardiovascular diseases
Conditions
Interventions
Group of patients who received sivelestat sodium:None
Group of patients who did not receive sivelestat sodium:None
Sponsors
Nanjing Drum Tower Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Receive heart surgery under extracorporeal circulation; 2. Acute lung injury occurred after surgery (PaO2/FiO2<300 mmHg); 3, No gender limit, aged 18-80 years; 4. Sign informed consent.
Exclusion criteria
Exclusion criteria: 1. Preoperative hepatic and renal insufficiency (EGFR < 35ml/min/1.73m^2; Child Pugh B or C); 2. Severe hypocardiac syndrome or multiple organ dysfunction after surgery; 3. Estimated survival time <72h; 4. Respiratory failure caused by heart failure or fluid overload; 5. Central respiratory failure or severe mechanical lung injury caused by stroke after surgery; 6. Preoperative complications of pulmonary diseases, such as clearly diagnosed pneumonia, tuberculosis, pleurisy and restricted ventilation dysfunction (FEV1 < 70%pred or clinically diagnosed obvious airway obstructive disease, bronchiectasis or pulmonary interstitial fibrosis with an area of more than 20% lung volume); 7. Pregnant or lactating patients or patients who may be pregnant; 8. History of malignant tumor, autoimmune disease or infectious disease; 9. Died during surgery.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Perioperative respiratory adverse events; | — |
Secondary
| Measure | Time frame |
|---|---|
| Mortality;Total length of stay;Length of ICU stay;Mechanical ventilation duration; | — |
Countries
China
Contacts
Public ContactWang Dongjin
Outcome results
None listed