Construction of culprit plaque typing model for acute myocardial infarction based on proteomics and metabolomics methods and related clinical prognosis research

Status

Recruiting

Phases

Early Phase 1

Study type

Observational

Source

ChiCTR

Registry ID

ChiCTR2200059095

Enrollment

Unknown

Registered

2022-04-24

Start date

2021-09-01

Completion date

Unknown

Last updated

2024-02-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acute myocardial infraction

Interventions

Plaque erosion group :None

Paque rupture group :None

Eligibility

Sex/Gender

All

Age

18 Years to 90 Years

Inclusion criteria

Inclusion criteria: 1. Patients older than 18 years; 2. Patients who are clearly diagnosed with acute myocardial infarction and require interventional therapy; diagnostic criteria for acute myocardial infarction: (1) STEMI diagnostic criteria: cTn>99% upper limit of normal reference value (ULN) or CK-MB>99hULN, ECG showed ST segment arched dorsal elevation, accompanied by one or more of the following conditions: persistent ischemic chest pain; ultrasound; Cardiogram showing segmental wall motion abnormalities; coronary angiography abnormalities; (2) Diagnostic criteria for NSTEMI: cTn > 99% ULN or CK-MB > 99% ULN, accompanied by one or more of the following conditions: persistent ischemic chest pain; electrocardiogram showing ST segment depression or T wave low in new-onset NSTEMI Flat, inverted; echocardiogram showing segmental wall motion abnormalities; coronary angiography abnormalities; 3. Determine the culprit plaque, in this study, the determination of the culprit lesion was determined by coronary angiography and ECG examination results.

Exclusion criteria

Exclusion criteria: 1. Patients with a definite diagnosis of unstable angina pectoris (UA), the diagnostic criteria for unstable angina pectoris: cTn negative, ischemic chest pain, electrocardiogram showing transient ST segment depression UA or T wave flat and inverted, rare ST Segment elevation (vasospastic angina); 2. Cardiogenic shock, end-stage renal disease, severe liver damage, allergy to contrast agents, and allergy to aspirin and clopidogrel; 3. Chronic total occlusive disease, left main stem disease, severe calcified disease, severe tortuosity of blood vessels, etc., for which it is difficult to perform OCT examination; 4. Those who have received coronary artery bypass grafting or stent implantation in the culprit lesion.

Design outcomes

Primary

Measure	Time frame
Characteristics of Culprit Lesion;	—

Countries

China

Contacts

Public ContactYan Fang

The 2nd Affiliated Hospital of Harbin Medical University

fangyan5668@163.com+86 13836112917

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026