Neurocritical medicine
Conditions
Interventions
Remimazolam besylate group:Remimazolam besylate loading dose 0.2mg kg-1,maintained at 0.1 ~ 0.45mg kg-1·h-1.
Propofol group:Propofol loading dose 2.5mg kg-1 ,maintained at 3~8mg kg-1 ·h-1.
Sponsors
First People's Hospital of Tianshui
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1. There was a clear history of acute craniocerebral trauma; 2. Emergency craniocerebral CT or MRI examination confirmed craniocerebral injury; 3. GCS score <= 8; 4. Emergency craniotomy; 5. Heart rate and blood pressure were stable; 6. There were no significant organic pathological changes in heart, liver, lung, kidney and other organs; 7. There was no recent history of surgery and trauma.
Exclusion criteria
Exclusion criteria: 1. Cerebrovascular history; 2. Intracranial space-occupying lesions, ruptured intracranial aneurysms; 3. Mental disorders, cognitive impairment; 4. Patients complicated with immune diseases, patients with long-term use of hormones; 5. Patients with major trauma in other parts of the body; 6. Ophthalmic diseases such as optic nerve tumor, glaucoma, optic neuritis, severe ocular trauma, etc.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Richmond Agitation-Sedation Scale (RASS);The time of mechanical ventilation;ICU stay time;Heart Rate Variability (HRV) ; | — |
Secondary
| Measure | Time frame |
|---|---|
| Cerebral Extraction of Oxygen (CEO2);[D-(a-jv)O2];Pcv-aCO2; | — |
Countries
China
Contacts
Public ContactLu Ming
First People's Hospital of Tianshui
Outcome results
None listed