Rhegmatogenous retinal detachment
Conditions
Interventions
Experimental group:Silicone oil removal in 2 months
Control group:Oil extraction time in 4 months
Sponsors
Xuzhou First People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Voluntary participation in the study and good compliance; 2. Patients with primary rhegmatogenous retinal detachment older than 18 years old and involving macular fovea; 3. Off-grid time <= 2 weeks; 4. Patients who are in good general condition and can tolerate the operation; 5. Patients who are judged to need ciliary body pars plana vitrectomy (PPV) + so filling.
Exclusion criteria
Exclusion criteria: 1. High refractive error (spherical equivalent greater than 6), high myopia (axial length = 26.0 mm) and inter ocular axial length difference greater than 0.3 mm were excluded; 2. Other accompanying eye diseases (diabetic retinopathy, glaucoma, age-related macular degeneration, uveitis, retinal vascular disease or retina of any eye); 3. Postoperative complications (re detachment, proliferative vitreoretinopathy, intraocular pressure higher than 21 mmHg or vitreous hemorrhage); 4. History of previous intraocular surgery; 5. the other eye of the patient did not carry out EDI-OCT and OCTA examination, or EDI-OCT and OCTA examination showed that the scanning quality was poor (image quality below 6 points), measurement error (such as segmentation error, alignment error or fixed error) or artifact (defocus, blink, or motion artifact); 6. Patients who are participating in other clinical trials; The researchers believe that other reasons are not suitable for clinical trials.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Glutamate;Methyl aspartate receptor;Interleukin-6;Interleukin-8;Interleukin-10;Interleukin-12;Vascular endothelial growth factor;Placental growth factor;Tumor necrosis factor-a;Total nitric oxide;Malondialdehyde;Total antioxidant;Glutathione;Choroidal vascular index;Subfoveal choroidal thickness;Retinal nerve fiber layer thickness;Ganglion cell layer thickness;Thickness of each layer from plexiform layer to photoreceptor layer in retina;Reset rate;Best corrected visual acuity;Magnesium ion;Calcium ion;Potassium ion;Sodium ion;Chloride ion; | — |
Secondary
| Measure | Time frame |
|---|---|
| Optic disc blood flow density;Macular blood flow density;Emulsification degree of silicone oil;Measure the deformation degree of visual object with M-CHARTS table;Multifocal ERG; | — |
Countries
China
Contacts
Public ContactHaiyang Liu
Xuzhou First People's Hospital
Outcome results
None listed