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ED50 of intrathecal administration of dexmedetomidine combined with ropivacaine for cesarean section

ED50 of intrathecal administration of dexmedetomidine combined with ropivacaine for cesarean section

Status
Active, not recruiting
Phases
Phase 1
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2200059072
Enrollment
Unknown
Registered
2022-04-23
Start date
2022-05-03
Completion date
Unknown
Last updated
2024-02-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cesarean section under spinal anesthesia

Interventions

1 group:ropivacaine +dexmedetomidine

Sponsors

Guangzhou Women and Children's Medical Center
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
18 Years to 45 Years

Inclusion criteria

Inclusion criteria: 1. Elective for cesarean section under combined spinal and epidural anesthesia; 2. Term gestation (>= 37 weeks), singleton pregnancy; 3. ASA physical status I or II; 4. Aged 18 to 45 years; 5. Patients are willing to participate in the trial and signed the informed consent; 6. Nulliparous (parity=0) or primiparous (parity=1); 7. Planned breastfeeding after surgery.

Exclusion criteria

Exclusion criteria: 1. Body mass index >= 40 kg/m2; 2. Contraindications to spinal anesthesia (increased intracranial pressure, coagulopathy, or local skin infection); 3. Participant received antipsychotic or hypnotic medications, alcohol or drug abuse; 4. Severe pregnancy complications (gestational diabetes, gestational hypertension, heart disease, complete placenta previa, placental abruption, preeclampsia); 5. Use of Sedative or analgesic drugs 2 hours before surgery; 6. Allergy, intolerance or contraindication to drugs used in the study; 7. Known fetal abnormalities.

Design outcomes

Primary

MeasureTime frame
The success or failure of the intrathecal block;Satisfaction with analgesia ;

Secondary

MeasureTime frame
Sensory and Motor block leve ;Visceral traction response;Muscle relaxation;Shivering score and Sedation score;Pain score;Side effect;

Countries

China

Contacts

Public ContactXiaofei Mo

Guangzhou Women and Children's Medical Center

13560336485@163.com+86 13560336485

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026