Intraoperative hypotension
Conditions
Interventions
HPI group:Intraoperative hypotension prediction guide blood pressure management
Control group:Intraoperative non-hypotension prediction index guide blood pressure management
Sponsors
Xiangya Hospital, Central South University
Eligibility
Sex/Gender
All
Age
60 Years to 100 Years
Inclusion criteria
Inclusion criteria: 1. Age >= 60 years old; 2. Elective surgery and general anesthesia are planned; 3. Peripheral arterial catheterization is required and the estimated operation time is >= 2 hours; 4. American Society of Anesthesiologist (ASA) >= grade 2; 5. AKI risk index (>= 3 factors below): (1) Male; (2) Preoperative complicated with chronic congestive heart failure; (3) Preoperative complicated with chronic hypertension; (4) Perform abdominal surgery; (5) Ascites; (6) Mild to moderate renal insufficiency (preoperative serum creatinine > 1.2mg/dl or > 105.6 umol/l); (7) Combined with diabetes requires oral hypoglycemic drugs or insulin therapy.
Exclusion criteria
Exclusion criteria: 1. Preoperative complications included severe and difficult to control hypertension (SBP >= 180mmhg or DBP >= 110mmhg), hypertensive emergency, severe arrhythmia, valve stenosis, and severe intracardiac shunt; 2. CKD >= stage 4 (glomerular filtration rate < 30ml/min/1.73m2 or renal replacement therapy or end-stage renal disease); 3. Acute cardiovascular events: including acute heart failure and acute coronary syndrome; 4. Kidney-related surgery, liver surgery, neurosurgery and vascular surgery requiring clamping of large blood vessels are required; 5. The anesthesia method is intraspinal anesthesia or regional block instead of general anesthesia; 6. Preoperative sepsis or shock; 7. Preoperative use of vasoactive drugs is required to maintain blood pressure. Preoperative map is lower than 65 mmHg or controlled hypotension is required or blood pressure is maintained at a higher level rather than 65 mmHg; 8. Preoperative hypotension, MAP <= 65mmHg; 9. Participants are participating in another clinical study or refuse to participate in this clinical study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Composite outcome including SIRS or at least one of major organ dysfuction; | — |
Secondary
| Measure | Time frame |
|---|---|
| Time weight average of intraoperative hypotension;Use of crystalloid;Use of colloid;Length of hospital stay; | — |
Countries
China
Contacts
Public ContactWangyuan Zou
Xiangya Hospital, Central South University
Outcome results
None listed