Type 1 diabetes in children
Conditions
Interventions
Treament group:Sodium-glucose cotransporter 2 inhibitors combined with insulin
Control:Insulin combined with other drugs
Sponsors
First Affiliated Hospital of Xinjiang Medical University
Eligibility
Sex/Gender
All
Age
No minimum to 18 Years
Inclusion criteria
Inclusion criteria: 1. Voluntary signing of informed consent; 2. Male or female subjects under the age of 18; 3. Subjects must have type 1 diabetes (clinical diagnosis) for more than 1 years. 4. Glycosylated hemoglobin < 10%; 5. The average daily dose of insulin pump (CSII) is 0.6-2.0 U/kg.
Exclusion criteria
Exclusion criteria: 1. Last HbA1c 70 mmol/mol; 2. Subject has celiac disease; 3. Daily average carbohydrate intake < 130 g/day from 14 days food record prior to the intervention; 4. Any concomitant disease possibly affecting glucose control; 5. Any chronic medication possibly affecting glucose control.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Fasting plasma glucose;Postprandial plasma glucose;Glycated hemoglobin A1C (HbA1c);Total daily insulin dosage;Incidence of adverse events; | — |
Secondary
| Measure | Time frame |
|---|---|
| Incidence of diabetic ketoacidosis; | — |
Countries
China
Contacts
Public ContactMaimaiti·Mireguli
First Affiliated Hospital of Xinjiang Medical University
Outcome results
None listed