Peri-operative neurocognitive disorder
Conditions
Interventions
Group one:100% inhalation oxygen concentration
Group two:40% inhalation oxygen concentration
Sponsors
Air Force Medical Center, PLA
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Age >65 years old; 2. Elective surgery; 3. Require mechanical ventilation under general anesthesia; 4. Expected anesthesia time over 3 h; 5. Informed consent acquired; 6. Without audio or visual disabilities.
Exclusion criteria
Exclusion criteria: 1. Neural system diseases such as acute stroke, Alzheimer's disease, history of neurosurgery, Parkinson's disease; 2. Severe cardiac insufficiency (NYHA III or IV); 3. Severe respiratory insufficiency e.g. severe COPD or oxygenation index 35; 5. Surgery and mechanical ventilation treatment in the last 2 weeks; 6. Long-term use of sedatives, antidepressants, alcohol or drug abuse, etc. 7. Intraoperative anticholinergic agents such as atropine.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of post-operative delirium; | — |
Secondary
| Measure | Time frame |
|---|---|
| Complications of respiratory system;Incidence of postoperative cognitive dysfunction;Neural injury biomarkers and inflammatory parameters; | — |
Countries
China
Contacts
Public ContactTianzhu Tao
Air Force Medical Center, PLA
Outcome results
None listed