Infertility
Conditions
Interventions
Group 1:Early follicular-phase single dose GnRH-a long protocol
Group 2:GnRH-ant protocol
Sponsors
Third Affiliated Hospital of Zhengzhou University
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: 1. Women aged 20-38 who received IVF/ICSI cycle treatment for the first time due to infertility; 2. Normal testosterone, prolactin, and thyroid stimulating hormone levels (normal after adjustment); 3. AMH >= 4.5 ng/ml (32.13 pmol/L) or diagnosed as PCOS; 4. 18< BMI <28 kg/m2; 5. Sign informed consent and be willing to accept follow-up.
Exclusion criteria
Exclusion criteria: 1. Stage III / IV endometriosis; 2. Previous POR history; 3. The subject or spouse/sperm donor has a clear history of single gene inheritance or abnormal chromosome karyotype, which may have a serious health impact on the offspring; 4. Bilateral AFC (diameter 2-10mm) < 10; 5. There is hydrosalpinx visible under B-ultrasound; 6. Patients diagnosed with abnormal uterine cavity morphology (confirmed by three-dimensional B-ultrasound or hysteroscopy), including uterine malformations (mediastinal uterus, single horn uterus, double uterus), submucosal hysteromyoma or uterine cavity adhesion; 7. Patients planning PGT-assisted pregnancy; 8. The patient has a history of recurrent abortion (loss of 2 or more previous pregnancies, excluding biochemical pregnancy); 9. There are contraindications for assisted reproductive technology and pregnancy, or diseases with definite effects on pregnancy: including uncontrolled hypertension, heart disease with definite symptoms, uncontrolled diabetes, undiagnosed liver and kidney diseases, liver and kidney insufficiency, and severe anemia; Previous history of venous thrombosis, pulmonary embolism or cerebrovascular events, history of malignant tumors, suspected malignant tumors, undiagnosed abnormal uterine bleeding.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Persistent pregnancy rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Conception rate;Clinical pregnancy rate;Pregnancy loss rate;Number of retrieved oocytes;Incidence of OHSS (ovarian hyperstimulation syndrome);Cycle cancellation rate; | — |
Countries
China
Contacts
Public ContactGuan Yichun
Reproductive Medicine Center, The Third Affiliated Hospital of Zhengzhou University
Outcome results
None listed