Early Postoperative Cognitive Function
Conditions
Interventions
Experimental group:esketamine
Control group:normal saline
Sponsors
Union Hospital Tongji Medical College Huazhong University of Science and Technology
Eligibility
Sex/Gender
All
Age
65 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Aged >=65 years; 2. ASA Grade I-III; 3. Patients undergoing elective surgery for gastric and colorectal cancer in our hospital; 4. Operation time >=2h; 5. Body mass index (BMI) 18-30kg/m^2.
Exclusion criteria
Exclusion criteria: 1. Emergency surgery; 2. Patients with cognitive dysfunction determined by MMSE score before surgery; 3. Unable to understand Mandarin and communicate effectively; Severe visual and hearing impairment; 4. Sevoflurane, dexmedetomidine, glononium bromide, scopolamine, and changtonine were used during the study; 5. Patients with preoperative behavioral disorder or combined mental illness, use of psychotropic drugs (clozapine, risperidone, olanzapine, haloperidol, chlorpromazine, etc.), history of alcoholism and use of acetylcholine; 6. Preoperative complications of other vital organ dysfunction: severe circulatory system diseases (such as severe arrhythmia, hypertension, coronary heart disease, cardiac insufficiency) and history of cardiac surgery; Severe respiratory diseases (respiratory failure, severe chronic obstructive pulmonary disease,); Cerebral hemorrhage; Abnormal coagulation function; 7. Patients with contraindications to the use of esketamine: aneurysmal vascular disease (including thoracic aorta, abdominal aorta, intracranial and peripheral arterial vessels) or arteriovenous malformation, history of cerebral hemorrhage, history of glaucoma, untreated or undertreated hyperthyroidism, and patients with serious risk of hypertension or elevated intracranial pressure; Allergic to esketamine or any excipients.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The incidence of postoperative cognitive function 3 days after surgery; | — |
Secondary
| Measure | Time frame |
|---|---|
| The incidence of postoperative delirium 3 days after surgery;Comparison of hemodynamic indexes at different time points;Comparison of intraoperative central vascular adverse events;Postoperative pain degree;Intraoperative BIS value; | — |
Countries
China
Contacts
Public ContactLin Yun
Department of Anesthesiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Outcome results
None listed