Subject Cognitive Decrease (SCD), Mild Cognitive Impairment (MCI)
Conditions
Interventions
SCD A group (2mA):Transcranial direct current stimulation (tDCS)
SCD C group:Pseudotranscranial direct current stimulation
MCI A group (2mA):Transcranial direct current stimulation (tDCS)
MCI C group:Pseudotranscranial direct current stimulation
SCD B group (2mA):Transcranial direct current stimulation (tDCS)
MCI B group (2mA):Transcranial direct current stimulation (tDCS)
Healthy control group:Immediate stimulation
Sponsors
The People's Hospital of Guangxi Zhuang Autonomous Region
Eligibility
Sex/Gender
All
Age
55 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Patients who meet the diagnostic criteria of SCD and MCI respectively; 2. Patients aged between 55 and 80 years; 3. Patients with right handedness; 4. Patients with informed consent and voluntary participation.
Exclusion criteria
Exclusion criteria: 1. Patients with cognitive decline or impairment caused by other reasons; 2. Patients with history of mental sickness; 3. Patients with history of smoking,drinking or drug abuse; 4. Patients with hypertension, hyperlipidemia and diabetes; 5. Patients who can not cooperate with assessment and test; 6. Patients with contraindications of MRI; 7.Patients who had previously used other drugs that may cause changes in cognitive function or failure of important organs such as cardio-cerebral and renal organs were included.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Mini-mental state examination;Montreal cognitive assessment;Clinical dementia rating ;Geriatric depression scale;Audio verbal learning test;Animal fluency test;30-item Boston naming test;Trail making test;Brain function BOLD data;Brain 3D-T1WI data;Brain ASL data;Brain MRS data;Brain DTI data;Adverse reaction table score;Functional activity questionnaire;Hamilton Depression Scale;Hamilton Anxiety Scale;Abbreviated geriatric depression scale;Neuropsychiatric scale;Pittsburgh Sleep Quality Index Scale;REM Sleep Behavioral Disorder Scale;Epvoss Sleepiness Scale; | — |
Countries
China
Contacts
Public ContactLiu Ying
The People's Hospital of Guangxi Zhuang Autonomous Region
Outcome results
None listed