pediatric acute liver failure (PALF)
Conditions
Interventions
Sponsors
Children's Hospital of Chongqing Medical University
Eligibility
Sex/Gender
All
Age
No minimum to 18 Years
Inclusion criteria
Inclusion criteria: 1. In patients with no prior evidence of chronic liver disease, liver failure occurs within 8 weeks of clinical liver disease. 2. Biochemical evidence of acute liver injury, typically elevated AST, ALT, and/or total bilirubin and bound bilirubin. 3. Thrombin time (PT)>=15 seconds, or international normalized ratio (INR)>=1.5 were not corrected by vitamin K. 4. Clinical evidence of encephalopathy -- patients with INR>1.5 but =20 seconds or INR>=2.0).
Exclusion criteria
Exclusion criteria: Children who abandoned treatment within 48 hours of admission.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Survival in 30 days;Spontaneous bleeding situation; | — |
Secondary
| Measure | Time frame |
|---|---|
| White blood cell;Neutrophilic granulocyte;Hemoglobin;Platelets;Total bilirubin;Conjugated bilirubin;Unconjugated bilirubin;Total protein;Albumin;Alanine aminotransferase;Aspartate aminotransferase;Lactate dehydrogenase;Gamma-glutamyl transpeptidase;Blood urea nitrogen;Creatinine;Fibrinogen;Prothrombin time;International normalised ratio;Total cholesterol;Triglycerides;High density lipoprotein-cholesterol;Low density lipoprotein-cholesterol; | — |
Countries
China
Contacts
Public ContactWang Ruijue
Children's Hospital of Chongqing Medical University
Outcome results
None listed