None listed
Conditions
Interventions
C0 Group:The initial dosage of ciprofol was 1.6mg/kg ,an increment or decrement of 0.05mg/kg was made based on the previous patients "three-point, six-category scale" response to the first attempt of
C1 Group:2min after 1ug/kg fentanyl, the initial dosage of ciprofol was 0.6mg/kg , An increment or decrement of 0.05mg/kg was made based on the previous patients response to the first attempt of LMA i
C2 Group:2min after 2ug/kg fentanyl, the initial dosage of ciprofol was 0.6mg/kg , An increment or decrement of 0.05mg/kg was made based on the previous patients response to the first attempt of LMA i
Sponsors
The 2nd Affiliated Hospital of Wenzhou Medical University
Eligibility
Sex/Gender
All
Age
3 Years to 6 Years
Inclusion criteria
Inclusion criteria: 1. Prior to the commencement of any activities related to the study, the subject's legal guardian shall obtain informed consent, be fully aware of the purpose and significance of the study, and be willing to comply with the test protocol; 2. Preschool children aged 3-6 years; 3. American Anesthesiologist Grade (ASA) I; 4. Subjects undergoing laparoscopic pediatric hernia repair under general anesthesia; 5. Meet the weight criteria.
Exclusion criteria
Exclusion criteria: 1. Difficult airway and severe respiratory diseases, acute respiratory infections, uncontrolled asthma and unexplained dyspnea; 2. Paediatric populations in need of special care or supervision by courts/social welfare institutions; 3. Subjects with mental system diseases, cognitive dysfunction, and epilepsy history; 4. Subjects with cardiovascular diseases (such as congenital heart disease, bradycardia requiring treatment, hypotension requiring treatment, etc.); 5. Subjects with abnormal liver function, ALT and/or AST>1.5 times the upper limit of normal; Subjects whose total bilirubin exceeds the upper limit of normal; Subjects with abnormal renal function and serum creatinine exceeding the upper limit of normal; 6. Use of sedative hypnotics (including benzodiazepines such as diazepam and barbiturates such as phenobarbital) or other analgesics (such as systematic use of NASIDs) within 7 days before surgery; 7. Participated in other clinical trials (received test drug or placebo) within 3 months before surgery; 8. Allergic to propofol, opiates and other drug ingredients or components; 9. Other conditions deemed unsuitable for participation in this clinical trial by the investigator.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| the ED50 of ciprofol in three group; | — |
Secondary
| Measure | Time frame |
|---|---|
| consciousness loss time (MOAA/S =1) after ciprofol injection;mean blood pressure;heat rate;pulse oxygen saturation;Awakening time in PACU; | — |
Countries
China
Contacts
Public ContactShangguan Wangning
The 2nd Affiliated Hospital of Wenzhou Medical University
Outcome results
None listed