Major Depressive Disorder
Conditions
Interventions
intervention group1:cathode tDCS+iTBS
intervention group2:sham tDCS+iTBS
Sponsors
Beijing Anding Hospital, Capital Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1. Outpatients aged 18-60 years, regardless of gender; 2. According to the M.I.N.I.6.0.0 stereotyped interview, it conforms to the diagnostic criteria for major depressive disorder (DSM-IV) of the Diagnostic and Statistical Manual of Mental Disorders (DSM-IV), with single or repeated attacks; 3. At baseline, HAMD-17 = 14 points; 4. Sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Have a history of neurological diseases, including head trauma, epilepsy, encephalitis, brain tumor, etc; 2. Persons currently eligible for other important psychiatric diagnoses, including neurocognitive impairment, neurodevelopmental disorder, schizophrenia, bipolar disorder, secondary depression, obsessive compulsive disorder, panic disorder, post-traumatic stress disorder, alcohol (or drug) dependence or abuse, and personality disorders; 3. High suicide risk, defined as =3 points in item 3 of HAMD-17; 4. Patients with moderate or above EEG abnormality, or mild EEG abnormality with clinical significance; 5. Major physical diseases or unstable physical conditions; 6. Abnormal items in the subjects' vital signs, laboratory examination and ECG examination, which are judged by the investigator to have significant clinical significance, will affect the safety of the subjects or the test results; 7. Patients with metal implants, pacemakers or metal clips in the arteries; 8. Screening patients who had received ECT, TMS, VNS, DBS or light treatment within the previous 3 months; 9. Patients with refractory depression, defined as having inadequate efficacy after adequate treatment with two antidepressants;Inadequate efficacy was defined as an improvement of < 50% in the severity of major depressive disorder as measured by the Antidepressant Treatment Efficacy Questionnaire (ATRQ).Adequate antidepressant treatment is defined as antidepressant treatment at the lowest dose (or higher dose) as detailed in the ATRQ for a duration of at least 6 weeks; 10. Those who had taken antidepressants, mood stabilizers, antipsychotics, antianxiety drugs and benzodiazepines within two weeks before enrollment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| change of score of HAMD-17 compared with baseline assessment;change of score of MADRS compared with baseline;change of score of MCCB compared with baseline;response rate;remission rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| change of score of HAMA compared with baseline;change of score of QIDS-SR16 compared with baseline;change of score of CGI-S compared with baseline;change of score of GAD-7 compared with baseline;laboratory test;change of score of PDQ-D compared with baseline; | — |
Countries
China
Contacts
Public ContactWang Zhimin
Beijing Anding Hospital, Capital Medical University
Outcome results
None listed