postoperative pain
Conditions
Interventions
S1:Esketamine 0.5mg/kg + hydromorphone 0.1mg/kg + tropisetron (0.2mg/kg) + normal saline was prepared into 150mL solution
S2:Esketamine 1.0mg/kg + hydromorphone 0.1mg/kg + tropisetron (0.2mg/kg) + normal saline was prepared into 150mL solution
S3:Esketamine 2.0mg/kg + hydromorphone 0.1mg/kg + tropisetron (0.2mg/kg) + normal saline was prepared into 150mL solution
H:Hydromorphone 0.1mg/kg + tropisetron (0.2mg/kg) + normal saline was prepared into a 150mL solution.
Sponsors
Department of Anesthesiology, Affiliated Cancer Hospital and Institute of Guangzhou Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: (1) Aged between 18 and 65; (2) Patients who underwent thoracoscopic (VATS) assisted thoracic surgery under bronchial intubation and general anesthesia, including segmental resection, lobectomy, sleeve resection, and total pulmonary resection; (3) Duration of operation and general anesthesia =2 hours, postoperative hospital stay at least 2 days; (4) Good cardiopulmonary function, no obvious surgical contraindications; (5) body mass index (BMI)=18kg/m2 and =30kg/m2; (6) Patients participated voluntarily and signed informed consent.
Exclusion criteria
Exclusion criteria: (1) Participating in other clinical trials within the past 3 months; (2) A history of dementia, psychosis or other central nervous system diseases; (3) Inability to understand Mandarin or Cantonese; (4) Patients allergic to esketamine; (5) Intracranial hypertension, glaucoma, hyperthyroidism; (6) Sick sinus syndrome, more than second degree atrioventricular block, sinus bradycardia (HR 100bpm); (7) taking sedatives, antidepressants or hormones; (8) Alcohol or drug dependence; (9) Patients are generally in poor condition, have a history of serious diseases of cardiovascular system, respiratory system, liver and kidney system, central nervous system, or have widespread tumor metastasis, and may not survive for more than 3 months; (10) Patients with poor preoperative blood pressure control (preoperative baseline value over 180/100 mmHg); (11) ASA Grade ? or ?
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The proportion of patients experiencing moderate-to-severe pain within the first 48 h; | — |
Secondary
| Measure | Time frame |
|---|---|
| Postoperative patient-controlled intravenous analgesia (PCIA) hydromorphone consumption;NRS score, Ramsay sedation score and postoperative recovery quality score were measured after extubation, 4h, 24 h and 48h;Incidence of postoperative adverse reactions;QoR-15 scores before, 24 and 48 hours after surgery;Baker Depression Scale score (BDI) and Simple Mental State Examination Scale score (MMSE) before surgery, 24h after surgery and 48h after surgery; | — |
Countries
China
Contacts
Public ContactYao Yonghua
Affiliated Cancer Hospital and Institute of Guangzhou Medical University
Outcome results
None listed