Subjective cognitive decline,Mild cognitive impairment,Alzheimer's disease
Conditions
Interventions
Sponsors
The Second Affiliated Hospital of Bengbu Medical College
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1.Age between 45-75 years old; 2.SCD complies with the 2018 "Expert Consensus on Diagnosis Process and Specification of Preclinical Subjective Cognitive Decline in Alzheimer's Disease in China", that is, subjective sensory memory decline rather than other cognitive impairment, and there is concern about cognitive decline. 3.MCI meets the diagnostic criteria for MCI promulgated by the American Academy of Neurology in 2018, and does not meet the diagnostic criteria for AD promulgated by the National Institute on Aging-Alzheimer's Association (NIA-AA) in 2011; 4.The patient has good compliance and can cooperate with the collection of clinical data and the evaluation of cognitive function.
Exclusion criteria
Exclusion criteria: 1. Accompanied with serious system complications or complications; 2. Those who have a history of symptomatic stroke, Parkinson's disease, anxiety, depression and other mental disorders and systemic diseases leading to cognitive impairment; 3. Previous diagnosis of central system infectious diseases, epilepsy, intracranial tumors or degenerative diseases of central nervous system; 4. Chronic insomnia, long-term use of sleeping pills, CO or chemical poisoning, and long-term drinking; 5. People with serious visual and hearing impairment and aphasia; 6. Patients with obvious intracranial and extracranial vascular stenosis; 7. Persons with contraindication of magnetic resonance examination and severe claustrophobia.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| cerebral blood flow;Plasma Aß;neuropsychological testing;Clinical Prediction Model; | — |
Countries
China
Contacts
Public ContactZhu Fangfang
The Second Affiliated Hospital of Bengbu Medical College
Outcome results
None listed