HIV-HBV Co-infected Patients
Conditions
Interventions
PEG-IFN combined treatment group:PEG-IFN a-2b treatment + ART drugs
Control group:ART drugs
Sponsors
Tianjin Second People's Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Aged 18-65 years; 2. HIV-1 infection; 3. HBsAg positive, with or without HBeAg positive; 4. HBsAg quantification200/ µ L; 8.HIV RNA=50copies/mL.
Exclusion criteria
Exclusion criteria: 1. Current opportunistic infection or AIDS related malignant tumor; 2. Anti HBV regimen without TDF/TAF, 3TC/FTC<6 months; 3. decompensated cirrhosis; 4. Abnormal thyroid function; 5. Autoimmune disease; 6. HCV RNA positive; 7. HDV IgG positive; 8. Creatinine clearance rate<60 ml/min; 9. Pregnant and lactating women; 10. Have a birth plan; 11. Current drug users; 12. Patients with serious mental and neurological diseases; 13. Those who have a history of alcoholism and cannot stop drinking; 14. Severe peptic ulcer; 15. Serious cardiovascular disease; 16. Acute and chronic pancreatitis; 17. Subjects considered unsuitable by other investigators.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| HBsAg seroclearance rate and HBsAg seroconversion rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| The level of HBsAg quantitative;Seroconversion rate of HBeAg in patients with HBeAg; | — |
Countries
China
Contacts
Public ContactPing Ma
Tianjin Second People's Hospital
Outcome results
None listed