Schizophrenia and psychotic disorders
Conditions
Interventions
control group:NO
SCZ patient group:Routine treatment
Sponsors
Luxian Lv
Eligibility
Sex/Gender
All
Age
18 Years to 55 Years
Inclusion criteria
Inclusion criteria: SCZ admission criteria: 1. In the acute stage of the disease, it meets DSM-5 diagnostic criteria, the course of the disease does not exceed 3 years, and the Positive and Negative Syndrome Scale (PANSS) = 60 points; 2. Han nationality, 18-55 years old, BMI of 18.5-23.9kg/m2, and at least one guardian shall monitor the patient within one year; 3. It is estimated that there will be no problems such as relocation of residence, inconvenient transportation, and difficulty in medical treatment during the whole study process; 4. Obtain the informed consent of the patient and guardian, and sign the informed consent form; Inclusion criteria for healthy and normal persons: 1. Be in good health and have no mental illness meeting DSM-5 diagnostic criteria; 2. No family history of mental illness; 3. No serious physical disease; 4. Han nationality, 18-55 years old; 5. There is no statistical difference between the gender, education level and the patient group; 6. Be able to cooperate in completing the evaluation of the project and sign the informed consent form; 7. No contraindication of magnetic resonance imaging (MRI).
Exclusion criteria
Exclusion criteria: Criteria for inclusion and exclusion of SCZ patients: 1. Co morbidity of immune diseases and serious somatic diseases or alcohol abuse; 2. Serious physical disability, unable to complete follow-up; 3. People suffering from other serious mental diseases, mental retardation, dementia and severe cognitive impairment; 4. Currently receiving or preparing to receive other clinical studies; 5. Have definite physical diseases such as hypertension and diabetes; 6. Laboratory examination shows liver and kidney function damage or other serious physical diseases and metabolic disorders; 7. Pregnant women or breast-feeding period. Exclusion criteria for healthy normal people: 1. Have a history of infectious diseases, immune system disease and substance dependence within two weeks; 2. Brain trauma, epilepsy or other organic brain diseases; 3. Have definite physical diseases such as hypertension and diabetes; 4. Laboratory examination shows liver and kidney function damage or other serious physical diseases and metabolic disorders; 5. Pregnant women or breast-feeding period.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| DSM-5;PNASS;MATRICS Consensus Cognitive Battery;Proteomics assay analysis;Animal behavior evaluation;Detection of inflammatory factors;Neural markers;Genetic testing for schizophrenia;Metabolomics testing; | — |
Secondary
| Measure | Time frame |
|---|---|
| Neuroimaging tests; | — |
Countries
China
Contacts
Public ContactLuxian Lv
The Second Affiliated Hospital of Xinxiang Medical University
Outcome results
None listed