Depression disorder
Conditions
Interventions
Adolescent Group:Medication combined with psychotherapy
Adult Group:Medication
Senile Group:Medication
control group:None
Sponsors
University City Hospital of Chongqing Medical University
Eligibility
Sex/Gender
All
Age
13 Years to 75 Years
Inclusion criteria
Inclusion criteria: Case group: 1. Interviews were conducted using the Mini International Neuropsychiatric Interview (MINI) (adult or child version), which met the DSM-5 diagnostic criteria for major depressive disorder; 2. Age 13-75 years old (including boundary value), gender is not limited, right-handed, primary school education or above; 3. Hamilton depression scale score = 17 points or children's depression scale (revised version) = 40 points;4. Hypomania symptom checklist (HCL-32) = 13 points to exclude bipolar disorder patients; 5. They did not use any psychotropic drugs or any antidepressant treatment 3 months before they were enrolled; 6. Patients and/or legal guardians voluntarily participated in the study, understood and signed written informed consent. Health control group: 1. No previous or current mental illness assessed by MINIKid; 2. Age 13-75 years old, right-handed, primary school education or above; 3. Patients and/or legal guardians voluntarily participated in the study, understood, and signed written informed consent.
Exclusion criteria
Exclusion criteria: Case group: ? Patients who were diagnosed as organic mental disorder, schizophrenia, schizoaffective disorder, bipolar affective disorder, mental retardation, dementia, other cognitive disorders, alcohol and drug dependence and personality disorder in DSM-5; ? Depression secondary to other mental diseases or somatic diseases; ? Patients with severe or unstable physical diseases; ? patients with epilepsy or other brain organic diseases; ? patients with a history of allergy to antidepressants;? Women who are lactating, pregnant or may be pregnant during the test period, and men who want to have children within one year; ? Those with contraindications to magnetic resonance imaging, such as newly implanted cardiac stents, metal dentures, etc. Health control group: 1. Patients with severe or unstable physical diseases; 2. Patients with previous or current brain organic diseases; 3. Family history of mental illness in two lines and three generations; 4. Women who are lactating, pregnant, or may be pregnant during the test period, and men who want to have children within one year; 5. Patients with contraindications to MRI, such as newly implanted cardiac stents, metal dentures, etc.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Brain magnetic resonance;Genomic DNA sequences;DNA methylation;Neurogenic exosome non-coding RNA;Neurogenic exocrine protein molecular;Hamilton Depression Scale;Revised Depression Rating Scale for Children; | — |
Secondary
| Measure | Time frame |
|---|---|
| Childhood Trauma Scale;Life Event Scale;Resilience Scale;Big Five Personality Inventory;Impulse behavior scale;Nine-item Patient Health Questionnaire;UKU Side Effect Scale;Gross Rating Scale;Sheehan Disability Scale; | — |
Countries
China
Contacts
Public ContactRan Liuyi
University City Hospital of Chongqing Medical University
Outcome results
None listed