Unipolar Depression, Bipolar Depression and Depression with Bipolarity
Conditions
Interventions
Gold Standard:DSM-V
Kiddle-Sads-PL
Diagnostic criteria for soft bipolar disorder proposed by Ghaemi.
Index test:Cortical excitability indicators of motor cortex : resting motor threshold (RMT), cortical resting period (CSP), short interval intercortical inhibition (SICI: 2ms, 4ms), long interval inte
Sponsors
Tianjin Medical University General Hospital
Eligibility
Sex/Gender
All
Age
12 Years to 18 Years
Inclusion criteria
Inclusion criteria: 1. Case group: Adolescent patients (12-18 years old) who meet the DSM-V diagnostic criteria for major depressive disorder in the psychological clinic and have not taken any psychiatric drugs in the past year are selected as case group, Hamilton Depression Scale (HAMD-17) >=17 points, Young's Manic Scale (YMRS) < 6 points; According to Ghaemi's diagnosis criteria for soft bipolar disorder, the patient group is divided into bipolar depression group (BD-I and BD-II), unipolar depression group (UD) and depression with bipolar disorder (DWB) group. 2. Control group: Adolescents who do not meet any diagnostic criteria of DSM-V mental disorders in ordinary middle schools in Tianjin are randomly selected as the healthy control group.Age: 12-18 years old, no gender limitation, HAMD-17 < 7, YMRS < 6; Voluntarily participate in the study and sign informed consent.
Exclusion criteria
Exclusion criteria: 1. Hearing and visual impairment; 2. History of severe physical disease or organic brain disease and traumatic brain injury; 3. Have received electroconvulsive therapy in the past year; 4. Drug, alcohol, or other substance abusers; 5. Failure to cooperate or complete the subject effectively during the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Cortical excitability;Cortical plasticity; | — |
Countries
China
Contacts
Public ContactYang Jianli
Tianjin Medical University General Hospital
Outcome results
None listed