Clinical study of velocity-time integral variability of left ventricle outflow track in predicting fluid responsiveness in critically ill postoperative patients

Status

Recruiting

Phases

Early Phase 1

Study type

Observational

Source

ChiCTR

Registry ID

ChiCTR2200058849

Enrollment

Unknown

Registered

2022-04-17

Start date

2022-04-20

Completion date

Unknown

Last updated

2024-01-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acute circulatory failure

Interventions

Gold Standard:Fluid responsiveness was defined as an increase >10% in SV (measured by TTE) after PLR maneuver

Index test:VTI variability and peak velocity variability of left ventricle outflow track by transthoracic doppler echocardiography

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: One or more of the following symptom(s) of acute circulatory failure: 1. Systolic blood pressure (SBP) 100 beats per minute); 4. Mottling of the skin; 5. Hyperlactatemia (>2 mmol/L).

Exclusion criteria

Exclusion criteria: 1. Age <18 years; 2. Left ventricular (LV) dysfunction (ejection fraction <40%); 3. Intracranial hypertension; 4. Active bleeding; 5. Intra-abdominal hypertension; 6. Arrhythmia; 7. Lower limbdisability; 8. Pregnant women; 9. Contraindication to the PLR maneuver; 10. The echocardiography could not be gained and poor echogenicit.

Design outcomes

Primary

Measure	Time frame
Maximal velocity-time integral;Minimal velocity-time integral;Maximal peak velocity;Minimal peak velocity;	—

Secondary

Measure	Time frame
Pulse pressure variation;Central venous pressure;Heart rate;Mean arterial pressure;Stroke volume;	—

Countries

China

Contacts

Public ContactJin Xie

The First Affiliated Hospital of Soochow University

xiejin728310@163.com+86 15806215256

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026