Treatment-resistant depression
Conditions
Interventions
Therapy Group:Implantable deep brain stimulation system
Sponsors
The Affiliated Brain Hospital of Guangzhou Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Meet the diagnostic criteria of "major depressive Disorder" in DSM-V; 2. Male and female, aged between 18 and 65, with stable vital signs; 3. Duration of current depressive episodes >=2 years, or recurrent episodes, number of episodes >=4 times (duration of current episodes >=1 year); 4. Refractory depression, at least 3 full treatment courses failed, including at least 2 different mechanisms of action of antidepressant drugs (SSRIs, SNRIs, NaSSAs, TCAs) full treatment courses (more than 8 weeks); Refusal, intolerance or poor response to non-convulsive electroconvulsive therapy; 5. Severity of symptoms: HAMD-17>=17 points; 6. In the last month, the antidepressant treatment regimen was stable; 7. Ability and willingness to provide written informed consent; 8. The patient has good compliance and can cooperate with follow-up.
Exclusion criteria
Exclusion criteria: 1. Schizophrenia or other psychotic symptoms; 2. Severe personality disorder; 3. History of severe neurological disorders such as seizures or cerebral hemorrhage or stroke; 4. Abnormal brain structure; 5. Previous history of stereotactic surgery; 6. Contraindications for general anesthesia or stereotactic neurosurgery; 7. Any circumstances (family support, medical psychosocial or geographical factors) that may now or in the future endanger the patient's safety or prevent the patient from successfully participating in the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Subtraction rate of Hamilton scale; | — |
Countries
China
Contacts
Public ContactYuping Ning
The Affiliated Brain Hospital of Guangzhou Medical University
Outcome results
None listed