Sudden hearing loss
Conditions
Interventions
A:intratympanic dexamethasone by 5mg/ml
B:intratympanic dexamethasone by 10 mg/ml
C:intratympanic dexamethasone by 15 mg/ml
Sponsors
Eye & ENT Hospital, Fudan University
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. According to AAO-HNS diagnostic criteria diagnosed as sudden deafness(Diagnostic criteria: sudden onset of unexplained sensorineural hearing loss within 72 hours, >=30dB of hearing loss at least three adjacent frequencies in 500, 1K, 2K, 4K, and 8K Hz.); 2. Any gender, ages 18 to 70 years; 3. Within 2 weeks of sudden onset of SSNHL; 4. Severe hearing loss: the average of pure tone hearing threshold >60dB(hearing loss on the day of enrollment); 5. Unilateral SSNHL; 6. Sign the informed consent and voluntary.
Exclusion criteria
Exclusion criteria: 1. There are known and clear causes of sudden deafness; 2. Previous history of Meniere's disease and hearing loss; 3. Prior to the onset of hearing abnormalities and balance dysfunction; 4. Pregnant and lactating women; 5. Taking or nearly 3 months may affect the symptoms characterization of drugs; 6. Patients complicated with other diseases, such as otitis media, severe cervical vertebra disease, fracture, etc., and unable to complete the examination items; 7. Patients with severe organ dysfunction; 8. Severe hypertension, more than 160/100mmHg; 9. Contraindications to hyperbaric oxygen, such as glaucoma, pulmonary bronchiectasis and myopia greater than 1000 degree; 10. Contraindications of hormones such as gastric ulcer, systemic fungal infection, liver function damage, hypothyroidism, renal function damage and tuberculosis; 11. Combined allergy on hormone or enlarge vascular drug, etc; 12. Patients participating in other drug or device clinical trials that did not meet the primary study endpoint.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pure tone audiometry; | — |
Countries
China
Contacts
Public ContactJing Wang
Eye & ENT Hospital, Fudan University
Outcome results
None listed