Colorectal cancer
Conditions
Interventions
Experimental group 1:Lidocaine was induced by 1.5mg/kg + maintained by 2mg/kg/h
Control group:Patients in the control group received an equal volume of saline as placebo administered at the same rate
Sponsors
Affiliated Hospital of North Sichuan Medical College
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1. Patients with radical colorectal cancer; 2. Age 18-60 years; 3. ASA grade I-III; 4. BMI: 20-30kg/m2.
Exclusion criteria
Exclusion criteria: 1. History of endoscopic submucosal dissection, radiotherapy, chemotherapy; or history of preoperative treatment with anti-inflammatory drugs, analgesics and hormones; 2. Metastases occurring in other distant organs; 3. Preoperative gastrointestinal obstruction or perforation; 4. Allergy to research drugs; 5. Severe hepatic or renal diseases; 6. Severe cardiac disease (severe arrhythmia, preexcitation syndrome, II or III atrioventricular block, double-bundle branch block), severe sinoatrial node dysfunction, congestive heart failure; 7. Psychiatric disorders; 8. Electrolyte disorders, seizure disorders, acid-base status, hypoxemia,hypoalbuminemia, low body weight (6 h), or serious adverse events occurring in the perioperative period or those transferred to the intensive care unit (ICU) after surgery were eliminated.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Interleukin-17; | — |
Secondary
| Measure | Time frame |
|---|---|
| intraoperative blood loss, intraoperative crystalline or colloidal infusion volume;Plasma concentration of lidocaine;QoR-40 (40 recovery quality rating scale);Postoperative gastrointestinal function;Postoperative chronic pain; | — |
Countries
China
Contacts
Public ContactTu Faping
Affiliated Hospital of North Sichuan Medical College
Outcome results
None listed