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To evaluate the effect of VHL expression intensity on the prognosis of adjuvant therapy after tumor reduction nephrectomy for advanced/metastatic clear cell renal carcinoma

To evaluate the effect of VHL expression intensity on the prognosis of adjuvant therapy after tumor reduction nephrectomy for advanced/metastatic clear cell renal carcinoma

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2200058782
Enrollment
Unknown
Registered
2022-04-17
Start date
2022-04-22
Completion date
Unknown
Last updated
2024-01-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Renal cancer

Interventions

None listed

Sponsors

Tongji Hospital, Tongji Medical College of Huazhong University of Science and Technology
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: 1. Renal clear cell carcinoma diagnosed by pathology; 2. Patients considered as advanced/metastatic clear cell renal carcinoma by imaging examination including PET-CT, CT or MRI: T4N0-1M0/T1-4N0-1M1; 3. Surgical tumor reduction treatment was performed; 4. ECOG score <= 2; 5. Renal cell carcinoma tissues can be obtained for immunohistochemical staining of VHL protein and CAIX protein.

Exclusion criteria

Exclusion criteria: 1. Patients with life expectancy is less than 1 year at the time of diagnosis of renal cell carcinoma; 2. Patients with other neoplastic diseases; 3. Renal cell carcinoma with other pathological types other than renal clear cell carcinoma; 4. Patients with severe liver function impairment in the diagnosis of renal cell carcinoma (Child-Pugh grade C); 5. Patients with severe renal function injury requiring long-term dialysis treatment when diagnosing renal cancer; 6. Patients with severe bone marrow suppression and severe neutropenia when diagnosing renal cell carcinoma.

Design outcomes

Primary

MeasureTime frame
Overall survival;

Secondary

MeasureTime frame
Progress-free survival;

Countries

China

Contacts

Public ContactHeng Li

Tongji Hospital, Tongji Medical College of Huazhong University of Science and Technology

lihengtjmu@163.com+86 18986292538

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026