Skip to content

Comparative study of denosumab and alendronate vitamin D3 on bone metabolism and bone mineral density after total hip arthroplasty

Comparative study of denosumab and alendronate vitamin D3 on bone metabolism and bone mineral density after total hip arthroplasty

Status
Active, not recruiting
Phases
Early Phase 1
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2200058773
Enrollment
Unknown
Registered
2022-04-16
Start date
2022-04-11
Completion date
Unknown
Last updated
2024-01-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Osteoporosis with hip fracture, necrosis of femoral head, congenital dysplasia of hip joint

Interventions

Group B:alendronate vitamin D3

Sponsors

Third Hospital of Hebei Medical University
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
50 Years to 80 Years

Inclusion criteria

Inclusion criteria: 1. The patient is preoperatively diagnosed as a disease requiring hip replacement; 2. Menopausal women who are older than 50 years old and younger than 80 years old; 3. The scope of operation is unilateral hip replacement; 4. Those who are not combined with severe cardiovascular and cerebrovascular diseases, liver and kidney insufficiency or malignant tumors and can tolerate surgery; 5. No history of long-term bed rest before the injury; 6. Patients voluntarily sign the informed consent.

Exclusion criteria

Exclusion criteria: 1. Combined with severe cardiovascular and cerebrovascular diseases, liver and kidney insufficiency or malignant tumors; 2. Those who have received osteoporosis drug therapy within 2-3 months before operation; 3. People who are bedridden for a long time.

Design outcomes

Primary

MeasureTime frame
Bone mineral density;Type 1 Collagen N-terminal Extended Peptide;ß-Collagen Degradation Products;Serum total calcium;

Countries

China

Contacts

Public ContactTao Wu

Third Hospital of Hebei Medical University

wutaodoctor@163.com+86 15511308787

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026